The triumph also lifted the 26-year-old back to the summit of the world rankings for the first time since August 2003 and this time she does not want to let go.
Serena Williams laid down an imposing marker ahead of the first grand slam of the year by powering to a 6-4, 7-5 victory over Australian Open champion Victoria Azarenka at the Brisbane International.
Maria Sharapova made it to her maiden semi-finals of the French Open by beating fellow Russian Anna Chakvetadze 6-3, 6-4.
There are only a certain number of ways to avoid addressing your chances of winning the Australian Open but Kim Clijsters found yet another on Sunday at Melbourne Park.
Top seed Nicole Vaidisova was dumped out of the Family Circle Cup on Tuesday in a second-round loss to Michaella Krajicek.
Coco Gauff claimed the biggest win of her young career on Friday with a stunning upset of defending champion Naomi Osaka at the Australian Open to reach the fourth round. Caroline Wozniacki and Serena Williams also lost their respective matches earlier in the day. Images from Day 5 of the Australian Open played at Melbourne Park on Friday.
Serena Williams may be the overwhelming favorite but the World No 1 is anything but a sure bet to win a U.S. Open overflowing with intriguing possibilities.
Along with film stars and fashion icons, sports stars and their better halves also showed off their whacky creations on the pink carpet.
Russia's Maria Sharapova booked her spot in the last four of the Australian Open on Wednesday with a surprisingly simple 6-2, 6-3 win over compatriot Ekaterina Makarova. She will face Czech Petra Kvitova.
Defending champion Serena Williams was knocked out by Jelena Jankovic in the quarter-finals of the Australian Open.
Defending champions Serena and Venus Williams defeated Cara Black and Liezel Huber 6-4, 6-3 to win the Australian Open women's doubles title on Friday, maintaining the partnership's perfect record in grand slam finals.
Serena Williams was left all alone trying to crush an unlikely uprising on Wimbledon's hallowed lawns on Tuesday as sister Venus and Kim Clijsters suffered shock defeats in the women's quarter-finals.
Petra Kvitova's hopes of defending her Wimbledon title were shot to pieces in a hail of Centre Court cannon fire from Serena Williams who ousted the defending champion 6-3, 7-5 in their quarter-final on Tuesday.
Serena Williams's health and gamesmanship were the subjects on everyone's lips at the French Open.
Maria Sharapova must be driving herself crazy every time she steps on court to face Serena Williams.
'She's a fighter on the court. She's playing really great, especially on the grass. She's attacking that ball really well. She doesn't let anything limit her'
Photos from the matches played at the Miami Open on Monday
American World No 1 Serena Williams will miss three tournaments in the build-up to the US Open due to surgery on her right foot, the WTA Tour said on Saturday.
IMAGES from the Women's Singles Final of the French Open at Roland Garros in Paris on Saturday.
Serena Williams stands just one match away from setting up another family showdown in the Wimbledon final after she hurtled into the last four with a 6-2, 6-3 win over Belarussian Victoria Azarenka on Tuesday.
Serena Williams' tactic of staying in her hotel room and being "boring" appears to be paying off after the world number one and top seed swept past Sara Errani into the final of the Madrid Open on Saturday.
The tournament will now begin on Tuesday, February 13.
The 37-year-old knows that if she wants to hoist the Rosewater Dish for an eighth time, she needs to improve in all departments.
The players from the States have won 34 Grand Slam singles titles in the last decade alone
Serena Williams beat France's Mathilde Johansson 6-2, 7-5 while Andy Murray disposed clay-specialist Jose Acasuso 6-4, 6-0, 6-4.
Defending champion Roger Federer was paired with familiar foe Alejandro Falla when the draw for next week's Wimbledon championships was made at the All England Club on Friday. Women's holder Serena Williams will face Portugal's Michelle Larcher di Brito.
Jelena Jankovic reached the semi-finals of the Sony Ericsson Open after Elena Dementieva retired with a back injury.
Victoria Azarenka suffered a stunning meltdown and blew three match points against world number one Serena Williams before losing 7-6(5), 3-6, 7-6(1) in the third round of the Madrid Open on Wednesday.
Champion Serena Williams, top seed Justine Henin and Rafael Nadal had things their way while booking fourth round slots at the Australian Open.
IMAGES from the Australian Open matches played on Friday.
Angelique Kerber said her dreams came true in just over two hours on Rod Laver Arena on Saturday when she upset defending champion Serena Williams 6-4, 3-6, 6-4 to win the Australian Open.
A display of violent hitting from Robin Soderling on Saturday showed why it is always unwise to ignore a Swede at the business end of Wimbledon as Serena Williams gave herself a 'must do better' report as she eased into round four.
World number one Serena Williams kept her Wimbledon title defence on track on Sunday, downing Germany's Annika Beck 6-3, 6-0 with a crushing display of power and booming serves to chalk up her 300th grand slam victory.
The American pulled out of the Hopman Cup match against Sania Mirza on Saturday after being down with a mild illness.
Serena was drawn on Friday to play doubles in a potentially decisive fifth rubber in this week's Fed Cup first round tie against the Netherlands in what will be her first competitive match in over a year. The doubles rubber, which is scheduled for Sunday on an indoor hard court in Asheville, North Carolina, will be played even if one side clinches the best-of-five match series through the opening four singles matches.
World No 1 Williams, 33, could not practise on Friday, still suffering from an illness that left her coughing and spluttering during her three-set semi-final win over Swiss Timea Bacsinszky.